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1

546 The PI3Kbeta/delta inhibitor AZD8186 combines with the dual mTORC1/2 inhibitor AZD2014 to give comprehensive PI3K pathway inhibition and drive tumour regression in vivo

Simon, B., Hancox, U., Polanska, U., Hanson, L., Dudley, P., Ellston, R., Maynard, J., Kraus, M., Curwen, J., Klinowska, T., Ward, L., Cruzalegui, F., Symeonides, S., Cronin, K.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

2

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Guichard, S. M., Curwen, J., Bihani, T., D'Cruz, C. M., Yates, J. W. T., Grondine, M., Howard, Z., Davies, B. R., Bigley, G., Klinowska, T., Pike, K. G., Pass, M., Chresta, C. M., Polanska, U. M., McE

Journal:

Molecular Cancer Therapeutics

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

3

Ultrasonic Investigations of Inclusion Complexation of α-Cyclodextrin by DMSO in Pseudo-Binary Aqueous System

Kaczmarek-Klinowska, Milena, Hornowski, Tomasz, Skumiel, Andrzej, Jażdżewska, Monika

Journal:

Archives of Acoustics

Year:

2015

Language:

english

File:

PDF, 268 KB

english, 2015

4

AZD8186 study 1: Phase I study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary anti-tumour activity of AZD8186 in patients with advanced castration-resistant prostate cancer (CRPC), squamous non-small cell lung cancer, triple negative breast cancer and with PTEN-deficient/mutated or PIK3CB mutated/amplified malignancies, as monotherapy and in combination with vistusertib (AZD2014) or abiraterone acetate

Lillian, S., De Bono, J., Higano, C., Shapiro, G., Brugger, W., Mitchell, P., Colebrook, S., Klinowska, T., Barry, S., Dean, E., Martin-Mills, J., Wisinski, K., Moorthy, G., Mills, J., Cruzalegui, F.,

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 53 KB

english, 2016

5

Cell–matrix interactions during development and apoptosis of the mouse mammary gland in vivo

Janine M. Prince, Teresa C.M. Klinowska, Emma Marshman, Emma T. Lowe, Ulrike Mayer, Jeff Miner, Daniel Aberdam, Dietmar Vestweber, Barry Gusterson, Charles H. Streuli

Journal:

Developmental Dynamics

Year:

2002

Language:

english

File:

PDF, 5.49 MB

english, 2002

6

Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics

Peter Ballard, Robert H. Bradbury, Craig S. Harris, Laurent F.A. Hennequin, Mark Hickinson, Jason G. Kettle, Jane Kendrew, Teresa Klinowska, Donald J. Ogilvie, Stuart E. Pearson, Emma J. Williams, Ing

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

7

Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, David G. Acton, Peter Ballard, Robert H. Bradbury, Darren Cross, Richard Ducray, Hervé Germain, Kevin Hudson, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivier, He

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

8

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, Peter Ballard, Robert H. Bradbury, Richard Ducray, Hervé Germain, D. Mark Hickinson, Kevin Hudson, Jason G. Kettle, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 134 KB

english, 2008

9

5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase

Peter Ballard, Robert H. Bradbury, Laurent F.A. Hennequin, D. Mark Hickinson, Paul D. Johnson, Jason G. Kettle, Teresa Klinowska, Remy Morgentin, Donald J. Ogilvie, Annie Olivier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

10

Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket

Peter Ballard, Robert H. Bradbury, Craig S. Harris, Laurent F.A. Hennequin, Mark Hickinson, Paul D. Johnson, Jason G. Kettle, Teresa Klinowska, Andrew G. Leach, Remy Morgentin, Martin Pass, Donald J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 245 KB

english, 2006

11

Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Peter Ballard, Bernard C. Barlaam, Robert H. Bradbury, Allan Dishington, Laurent F.A. Hennequin, D. Mark Hickinson, Ian M. Hollingsworth, Jason G. Kettle, Teresa Klinowska, Donald J. Ogilvie, Stuart E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 143 KB

english, 2007

12

Light and the pineal gland in the control of the breeding season in the female ferret

J. Herbert, P. A. Thorpe, M. Klinowska

Journal:

International Journal of Biometeorology

Year:

1975

Language:

english

File:

PDF, 110 KB

english, 1975

13

Transatlantic spread of seal virus

Journal:

Year:

1989

File:

PDF, 122 KB

1989

14

Thermophysical and Magnetic Properties of Carbon Beads Containing Cobalt Nanocrystallites

M. Izydorzak, A. Skumiel, M. Leonowicz, M. Kaczmarek-Klinowska, A. D. Pomogailo, G. I. Dzhardimalieva

Journal:

International Journal of Thermophysics

Year:

2012

Language:

english

File:

PDF, 835 KB

english, 2012

15

A new in vitro model of murine mesoderm migration: the role of fibronectin and laminin

Teresa C.M. Klinowska, Grenham W. Ireland, Susan J. Kimber

Journal:

Differentiation

Year:

1994

Language:

english

File:

PDF, 1.42 MB

english, 1994

16

Laminin and β1 Integrins Are Crucial for Normal Mammary Gland Development in the Mouse

Teresa C.M. Klinowska, Jesus V. Soriano, Gwynneth M. Edwards, Janine M. Oliver, Anthony J. Valentijn, Roberto Montesano, Charles H. Streuli

Journal:

Developmental Biology

Year:

1999

Language:

english

File:

PDF, 1.05 MB

english, 1999

17

Epithelial Development and Differentiation in the Mammary Gland Is Not Dependent on α3 or α6 Integrin Subunits

Teresa C.M. Klinowska, Caroline M. Alexander, Elisabeth Georges-Labouesse, Ronald Van der Neut, Jordan A. Kreidberg, Carolyn J.P. Jones, Arnoud Sonnenberg, Charles H. Streuli

Journal:

Developmental Biology

Year:

2001

Language:

english

File:

PDF, 1.07 MB

english, 2001

18

Cognitive flexibility but not cognitive coordination is affected in rats with toxic liver failure

Malgorzata Wesierska, Hanna D. Klinowska, Iwona Adamska, Inez Fresko, Joanna Sadowska, Jan Albrecht

Journal:

Behavioural Brain Research

Year:

2006

Language:

english

File:

PDF, 324 KB

english, 2006

19

368 Demonstration of broad in vivo anti-tumor activity of ARRY-142886 (AZD-6244), a potent and selective MEK inhibitor

P.A. Lee, E. Wallace, T.C. Yeh, G. Poch, D. Hunt, T. Pheneger, R. Woessner, S. Cartlidge, T. Klinowska, J.D. Winkler

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 137 KB

english, 2004

20

1033-117 Ventilatory response to early phase of exercise: An useful index for comprehensive clinical assessment of patients with heart failure and novel predictor of prognosis

Tomasz Witkowski, Ewa Jankowska, Robert Zymlinski, Agnieszka Kus-Klinowska, Waldemar Banasiak, Piotr Ponikowski

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 67 KB

english, 2004

21

1225 AZD8931, an equipotent, reversible inhibitor of erbB1, erbB2 and erbB3 receptor signalling: characterisation of pharmacological profile

T. Klinowska, M. Hickinson, G. Speake, G. Marshall, S. Beck, P. Smith, J. Vincent, J. Anderton, N. Gray, D. Ogilvie

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 73 KB

english, 2009

22

471 Inhibiting signalling by erbB receptor tyrosine kinases with AZD8931, a potent reversible small molecule inhibitor, reduces intestinal adenoma formation in the ApcMin/+ mouse model

D. Alferez, A. Logié, P. Seedhar, R. Poulsom, T. Klinowska, R.W. Wilkinson

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 45 KB

english, 2010

23

Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors

Barlaam, Bernard, Anderton, Judith, Ballard, Peter, Bradbury, Robert H., Hennequin, Laurent F. A., Hickinson, D. Mark, Kettle, Jason G., Kirk, George, Klinowska, Teresa, Lambert-van der Brempt, Christ

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

24

Therapeutic potential of the dual EGFR/HER2

Morrison, Gladys, Fu, Xiaoyong, Shea, Martin, Nanda, Sarmistha, Giuliano, Mario, Wang, Tao, Klinowska, Teresa, Osborne, C. Kent, Rimawi, Mothaffar F., Schiff, Rachel

Journal:

Breast Cancer Research and Treatment

Year:

2014

Language:

english

File:

PDF, 1.74 MB

english, 2014

25

Evaluation of Power Heat Losses in Multidomain Iron Particles Under the Influence of AC Magnetic Field in RF Range

Skumiel, Andrzej, Kaczmarek-Klinowska, Milena, Timko, Milan, Molcan, Matus, Rajnak, Michał

Journal:

International Journal of Thermophysics

Year:

2013

Language:

english

File:

PDF, 503 KB

english, 2013

26

AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models

Zhaomei Mu,Teresa Klinowska,Xiaoshen Dong…

Journal:

Journal of Experimental & Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

27

Exploring mechanisms of acquired resistance to HER2 (human epidermal growth factor receptor 2)-targeted therapies in breast cancer

Creedon, Helen, Byron, Adam, Main, Joanna, Hayward, Larry, Klinowska, Teresa, Brunton, Valerie G.

Journal:

Biochemical Society Transactions

Year:

2014

Language:

english

File:

PDF, 379 KB

english, 2014

28

491 Development and characteristics of resistance to the HER family tyrosine kinase inhibitor AZD8931

Brunton, V.G., Creedon, H., Muir, M., Klinowska, T., McLeod, K., Byron, A.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 57 KB

english, 2014

29

Lunar rhythms in activity, urinary volume and acidity in the golden hamster (Mesocricetus auratus Waterhouse)

Klinowska, Margaret

Journal:

Journal of Interdisiplinary Cycle Research

Year:

1970

Language:

english

File:

PDF, 223 KB

english, 1970

30

In living organisms

Klinowska, Margaret

Journal:

Journal of Interdisiplinary Cycle Research

Year:

1972

Language:

english

File:

PDF, 240 KB

english, 1972

31

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

Gavine, P. R., Mooney, L., Kilgour, E., Thomas, A. P., Al-Kadhimi, K., Beck, S., Rooney, C., Coleman, T., Baker, D., Mellor, M. J., Brooks, A. N., Klinowska, T.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.73 MB

english, 2012

32

Cetacean ‘Navigation’ and the Geomagnetic Field

Journal:

Journal of Navigation

Year:

1988

Language:

english

File:

PDF, 1.75 MB

english, 1988

33

Animal Navigation. Talbot Waterman. 243 pages, 24×22 cm, Scientific American Library, New York, 1989. ISBN 0 7167 5024 4. £14.95.

Klinowska, Margaret

Journal:

Journal of Navigation

Year:

1990

Language:

english

File:

PDF, 151 KB

english, 1990

34

AZD8931, an Equipotent, Reversible Inhibitor of Signaling by Epidermal Growth Factor Receptor, ERBB2 (HER2), and ERBB3: A Unique Agent for Simultaneous ERBB Receptor Blockade in Cancer

Hickinson, D. M., Klinowska, T., Speake, G., Vincent, J., Trigwell, C., Anderton, J., Beck, S., Marshall, G., Davenport, S., Callis, R., Mills, E., Grosios, K., Smith, P., Barlaam, B., Wilkinson, R. W

Journal:

Clinical Cancer Research

Year:

2010

Language:

english

File:

PDF, 880 KB

english, 2010

35

Melting of Eutectic Mixtures in Silica and Carbon Nanopores

Sliwinska-Bartkowiak, Małgorzata, Jazdzewska, Monika, Trafas, Marcin, Kaczmarek-Klinowska, Milena, Gubbins, Keith E.

Journal:

Journal of Chemical & Engineering Data

Year:

2015

Language:

english

File:

PDF, 3.44 MB

english, 2015

36

[Progress in Brain Research] Volume 52 || Seasonal Changes in the Sheep Pineal – The Preparation and Testing of Tissue Fractions

Year:

1979

Language:

english

File:

PDF, 475 KB

english, 1979

37

Urinary Retention and Cystitis Associated with Subcutaneous Estradiol Pellets in Female Nude Mice

Pearse, G., Frith, J., Randall, K. J., Klinowska, T.

Journal:

Toxicologic Pathology

Year:

2009

Language:

english

File:

PDF, 1.31 MB

english, 2009

38

Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer

Creedon, H., Balderstone, L. A., Muir, M., Balla, J., Gomez-Cuadrado, L., Tracey, N., Loane, J., Klinowska, T., Muller, W. J., Brunton, V. G.

Journal:

Disease Models & Mechanisms

Year:

2015

Language:

english

File:

PDF, 2.40 MB

english, 2015

39

Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models

Crafter, Claire, Vincent, John, Tang, Eric, Dudley, Phillippa, James, Neil, Klinowska, Teresa, Davies, Barry

Journal:

International Journal of Oncology

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

40

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

Hennessy, Edward J, Chuaqui, Claudio, Ashton, Susan, Colclough, Nicola, Cross, Darren A. E., Debreczeni, Judit É., Eberlein, Cath, Gingipalli, Lakshmaiah, Klinowska, Teresa C. M., Orme, Jonathan P, Sh

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.22 MB

english, 2016

41

[IEEE Computers in Cardiology, 2003 - Thessaloniki Chalkidiki, Greece (2003.09.24-2003.09.24)] Computers in Cardiology, 2003 - Home telemonitoring of respiratory activity and heart rate variability in chronic heart failure patients: the challenge of the home or hospital in heart failure project

Pinna, G.D., Maestri, R., Gobbi, E., La Rovere, M.T., Scanferlato, J.L., Witkowski, T., Kus-Klinowska, A., Andrews, D., Johnson, P., Capomolla, S., Mortara, A.

Year:

2003

Language:

english

File:

PDF, 402 KB

english, 2003

42

Requirement for β1 integrins in the development of mouse mammary gland

Klinowska, Teresa CM, Broomhead, Gary, Streuli, Charles H

Journal:

Biochemical Society Transactions

Year:

1996

Language:

english

File:

PDF, 104 KB

english, 1996

43

A first in human study of the new oral selective estrogen receptor degrader AZD9496 for HR+/HER2− advanced breast cancer

Hamilton, Erika P., Patel, Manish R., Armstrong, Anne C, Baird, Richard D, Jhaveri, Komal, Hoch, Matthias, Klinowska, Teresa, Lindemann, Justin P O, Morgan, Shethah, Schiavon, Gaia, Weir, Hazel M, Im,

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 4.35 MB

english, 2018

44

Circulating biomarkers and resistance to endocrine therapy in metastatic breast cancers: correlative results from AZD9496 oral SERD Phase I trial

Paoletti, Costanza, Schiavon, Gaia, Dolce, Emily M., Darga, Elizabeth P., Carr, Thomas H, Geradts, Joseph, Hoch, Matthias, Klinowska, Teresa, Lindemann, Justin P O, Marshall, Gayle, Morgan, Shethah, P

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 3.37 MB

english, 2018

45

Assembly and Rearrangement of Particles Confined at a Surface of a Droplet, and Intruder Motion in Electro-Shaken Particle Films

Rozynek, Zbigniew, Kaczmarek-Klinowska, Milena, Magdziarz, Agnieszka

Journal:

Year:

2016

Language:

english

File:

PDF, 4.27 MB

english, 2016

46

Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry

Scott, James S., Breed, Jason, Carbajo, Rodrigo J., Davey, Paul R., Greenwood, Ryan, Huynh, Hoan K., Klinowska, Teresa, Morrow, Christopher J., Moss, Thomas A., Polanski, Radoslaw, Nissink, J. Willem

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 484 KB

english, 2019

47

833PAZD8186, a potent and selective inhibitor of PI3Kβ/δ, as monotherapy and in combination with abiraterone acetate plus prednisone (AAP), in patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC)

de Bono, J S, Hansen, A, Choudhury, A D, Cook, N, Heath, E I, Higano, C, Linch, M, Martin-Liberal, J, Rathkopf, D E, Wisinski, K B, Barry, S, de Bruin, E, Brugger, W, Colebrook, S, Klinowska, T, Mosch

Journal:

Annals of Oncology

Year:

2018

File:

PDF, 99 KB

2018

48

HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

Tracey, Natasha, Creedon, Helen, Kemp, Alain J., Culley, Jayne, Muir, Morwenna, Klinowska, Teresa, Brunton, Valerie G.

Journal:

Breast Cancer Research and Treatment

Year:

2019

Language:

english

File:

PDF, 2.07 MB

english, 2019

49

HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

Tracey, Natasha, Creedon, Helen, Kemp, Alain J., Culley, Jayne, Muir, Morwenna, Klinowska, Teresa, Brunton, Valerie G.

Journal:

Breast Cancer Research and Treatment

Year:

2019

File:

PDF, 2.07 MB

2019